Titlebook: Blood Substitutes and Oxygen Biotherapeutics; Henry Liu,Alan D. Kaye,Jonathan S. Jahr Book 2022 The Editor(s) (if applicable) and The Auth

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Complications of HBOCs Including Clinical Safety Issuesization in human patients has been complicated by various factors such as differences in the products, failed clinical trials, differences in interpretation of study results and safety issues. This chapter will review the side effects and safety profiles of HBOC-related products, such as HemAssist,

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On the Oxidative Toxicity of Hemoglobinds oxygen. Autoxidation of Hb however, is relatively controlled during circulation and the level of accumulated oxidized Hb in RBCs is maintained at less than 3% of total Hb due to the action of endogenous antioxidant proteins. However, during the aging process and in disease states, such as hemoglo

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Perfluorocarbon-Based Oxygen Carriersased. Both provide oxygen transport to tissues. For several decades, perfluorocarbons have been explored as oxygen carriers in a variety of biological applications. Perfluorocarbons are chemically and physiologically inert, have excellent temperature and storage stability, represent little to no inf

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Platelet Substitutesnt of platelet substitutes. Platelet substitutes can be divided into red cell derivatives, liposomal derivatives, and nanoparticles. Unfortunately, to date, none of these technologies have advanced far enough to be commercially viable. Instead, the development of thrombopoietic agents and drugs to f

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Light scattering by superionic conductors,avoidance of reactions also involved balancing expected benefit against risks inherent in transfusions themselves. The threat of transfusion reactions expanded with recognition of newer entities in this category, the next threat of infectious disease transmission emerged, shocking the world by the H

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