Titlebook: Blood Substitutes; Physiological Basis R. M. Winslow,K. D. Vandegriff,M. Intaglietta Book 1995 Birkhäuser Boston 1995 Biologie.Medizin.bio

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Atmosphere of Finite Optical Thicknessation paradox resulting in vasoconstriction, impairment of functional capillary density, and increased microcirculatory metabolism, causing decreased tissue oxygenation. It is proposed that higher viscosity, left-shifted hemoglobin oxygen saturation solutions will fully oxygenate tissue.

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Basic Concepts, Equations and Problemsn to achieve local control in a proportion of such tumors. The central point is that under normal conditions there is a differential PO. distribution which favors the tumor relative to the normal tissue with respect to surviving radiation treatments. In reaction to this understanding of tumor biolog

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Transfusion Alternatives: Impact on Blood Banking Worldwide,cell substitutes. To do this job well, one would need to know the characteristics of each licensed red cell substitute, the sequence of licensure and their applications, costs, side effects, .. One would also like to know what other new technologies will have been introduced at the time of the intro

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A Physiologic Basis for the Transfusion Trigger,iven patient should be based on the need for transfusion, not just on an estimation of the risks. Transfusion requirements need to be understood on physiological grounds, but there is no clear-cut “transfusion trigger” that emerges from this understanding. Rather, the clinician must combine physiolo

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Design of Chemically Modified and Recombinant Hemoglobins as Potential Red Cell Substitutes,atives are prepared by treatment of hemoglobin with some chemical reagent to yield a product that possesses a property considered desirable for a blood substitute. The degree of sophistication of these derivatives has, in general, increased in proportion to our knowledge of hemoglobin itself.

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Encapsulation of Hemoglobin in Liposomes,ent work in this field is focused on the use of liposomes. Liposomes are biodegradable capsules which permit the diffusion of oxygen while encapsulating hemoglobin within an aqueous environment. The encapsulation of hemoglobin in liposomes extends the circulation persistence and alters the biodistri

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Red Cell Substitutes in the Kidney,nction (Hess .. 1989, Keipert and Chang 1987, Messmer 1978, Snyder .. 1987). However, this concern has been based upon models and assumptions that may not be entirely pertinent since direct studies have not as yet been performed in both euvolemic and hypovolemic models pertinent to the utility of re