Titlebook: Blood Stem Cell Transplantation; Jane N. Winter Book 1997 Springer Science+Business Media New York 1997 cell.cytokines.gene therapy.hemato

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The use of radiolabeled antibodies in bone marrow transplantation for hematologic malignancieselatively radiosensitive. Such preparative regimens have cured a substantial proportion of patients with both acute and chronic leukemia as well as lymphoma. However, despite the radiation sensitivity of hematologic malignancies, relapse remains a major cause of failure.

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J. Brandmüller,R. Claus,L. Merten suggests that this is an important immunologic mechanism that contributes to the success of transplantation by eradicating residual disease. This phenomenon is referred to as the . (GVL) effect. Hence, as suggested by Mathe, allogeneic BMT can be considered a successful form of ‘adoptive immunotherapy’ [1].