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Titlebook: Blood Stem Cell Transplantation; Jane N. Winter Book 1997 Springer Science+Business Media New York 1997 cell.cytokines.gene therapy.hemato

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发表于 2025-3-21 16:22:29 | 显示全部楼层 |阅读模式
期刊全称Blood Stem Cell Transplantation
影响因子2023Jane N. Winter
视频video
学科分类Cancer Treatment and Research
图书封面Titlebook: Blood Stem Cell Transplantation;  Jane N. Winter Book 1997 Springer Science+Business Media New York 1997 cell.cytokines.gene therapy.hemato
影响因子.Blood Stem Cell Transplantation. conveys the excitementthat accompanies the newest developments in hematopoietic stem celltransplantation. Some of the applications that stand to impact thisfield most significantly are based on recent advances in thebiological sciences, as demonstrated by the chapters on gene therapy,on the detection of minimal residual disease using moleculartechniques, and on the use of radioimmunoconjugates targeting lymphomaand leukemia-associated antigens. Others are the results of clinicalobservations - e.g., the association between graft-versus-host-disease (GVHD) and durable remissions that have led to creativeclinical experiments such as donor leukocyte infusions (DLI). Attemptsto unravel the biological events that underlie the responses seen inpatients with relapsed chronic myelogenous leukemia treated with DLIare likely to provide the basis for future refinements in thisclinical approach. Hopefully, improved response rates and reducedtoxicity will result. The power of the immunologic response incontrolling malignant disease is underscored in the chapter onpost-transplant immunotherapy. The complex immunologic process thatresults in clinical GVHD may be d
Pindex Book 1997
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发表于 2025-3-21 23:10:07 | 显示全部楼层
Post-bone marrow transplant use of immunotherapys accumulated over the past few decades and suggests that immune mechanisms are important for eradication of residual disease in the recipient [1–3]. The lack of GVT effect after autologous BMT (ABMT), along with reinfusion of clonogenic tumor cells with the autologous graft, may be responsible for
发表于 2025-3-22 01:18:07 | 显示全部楼层
Graft-versus-leukemia effect of allogeneic bone marrow transplantation and donor mononuclear cell inerapy, with or without radiotherapy, are administered to patients, and normal hematopoiesis is restored with the infusion of normal donor bone marrow. Yet despite intensive conditioning therapy, many patients have residual disease that can result in recurrent leukemia. The prevalence of these residu
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The detection of minimal residual disease: implications for bone marrow transplantationndard diagnostic techniques. Therefore, considerable effort has been made over the past decade to develop new techniques that have greatly increased the sensitivity of detection of small numbers of residual neoplastic cells. In particular, the identification of specific gene rearrangements and chrom
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Ex vivo expansion of hematopoietic stem and progenitor cells for transplantationtic cells. Ex vivo expanded hematopoietic cells are useful for a variety of clinical applications such as transplantation, tumor purging, and gene therapy. The anticipated benefits of ex vivo expanded hematopoietic cells over bone marrow or peripheral blood for transplant patients include a shortene
发表于 2025-3-23 04:28:59 | 显示全部楼层
Allogeneic umbilical cord blood transplantationgical malignancies, bone marrow failure syndromes, and selected hereditary immunodeficiency states and metabolic disorders. Use of allogeneic BMT has been limited both by the lack of suitable donors and because of the risk of life-threatening complications that arise when donor and recipient are not
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