| 期刊全称 | Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach | | 影响因子2023 | Francesco Saverio De Ponte | | 视频video | | | 发行地址 | First multidisciplinary text on the subject, by worldwide experts.Update of the latest advances, technical details, and expert advice regarding this subject.Presents multiple designs, explanatory figu | | 图书封面 |  | | 影响因子 | During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today‘s oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn‘t until 2003 that today‘s intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic boneof the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of thes | | Pindex | Book 2012 |
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发表于 2025-3-21 18:30:37
