Titlebook: Bispecific Antibodies; Roland E. Kontermann Book 2011 Springer-Verlag Berlin Heidelberg 2011 Cancer therapy.Hybridoma.Immunoglobulin.Immun

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https://doi.org/10.1007/978-3-642-66519-6nufacturing. Several DVD-Ig™ molecules have been constructed and characterized recently. In this chapter, we summarize the design considerations as well as functional, biophysical/biochemical, and pharmacokinetic properties of DVD-Ig™ molecules. As examples, we provide details from our previously pu

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Die Technik der kystoskopischen Untersuchungell conformational changes in amino acid side chains – allows the binding site to adapt with high shape complementary to the two structurally unrelated antigens. Further, the dual binding function of bH1 has been improved to high affinity and validated by the potent dual action . and ., showing the

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Technik des Harnleiterkatheterismusicacy is coupling of toxic payloads, such as chemotherapeutics or bacterial toxins (Alley et al. 2010). While the US market approval for the anti-CD33/calicheamycin conjugate Mylotarg., the first marketed drug of this kind, has been retracted in 2010, a novel generation of antibody drug conjugates (

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Technik des Harnleiterkatheterismusd antigen-presenting cells, respectively, in order to avoid side effects and vector sequestration. To this end, bispecific antibodies have been engineered as adapters that link the vector to a specific molecule on the targeted cell and at the same time block the interaction with the native virus rec

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pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed..978-3-642-43207-1978-3-642-20910-9

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Bispecific Antibodies: Developments and Current Perspectives, can be further improved by protein and/or glyco-engineering (Carter 2006; Kubota et al. 2009). However, natural antibodies also face certain limitations. For example, antibodies are not capable of recruiting T cells because these cells do not express Fc receptors. Also, monoclonal antibodies are mo

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Bispecific Single Domain Antibodies,em as ideal building blocks to elaborate multivalent and/or multispecific molecules. This chapter aims at giving an overview of the published work using single domain antibodies to create bispecific antibodies.

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,Tribodies: Fab–scFv Fusion Proteins as a Platform to Create Multifunctional Pharmaceuticals,vation of T-cell proliferation and cytotoxicity in vivo..This design allows easy engineering of multispecificity in a single molecule, e.g., bispecific antibodies bivalent for the target and monovalent for effector activation (e.g., for T-cell activation), or trispecific antibodies ..