| 期刊全称 | Bispecific Antibodies | | 影响因子2023 | Roland E. Kontermann | | 视频video | | | 发行地址 | Presents the recent advances in antibody engineering and in the various clinical applications.An invaluable resource for both experts and those new to the field.With contributions by international exp | | 图书封面 |  | | 影响因子 | .The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy..In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed.. | | Pindex | Book 2011 |
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发表于 2025-3-21 20:08:53
