Titlebook: Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy; Carlos A. Zarate,Husseini K. Manji Book 20091st editio

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Neuroimaging studies of bipolar depression: therapeutic implicationsc responses to stress, and hence emotion and behavior. Specifically, reductions in gray matter volume and a concomitant increase in glutamatergic neurotransmission, is observed in the pregenual (pgACC) and subgenual anterior cingulate cortex (sgACC), the orbitofrontal, frontal polar and ventrolatera

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Pharmacological treatment of acute bipolar depressions obligation to inform the patient of proven therapies that may exist to treat their condition. The best guidance for meeting this obligation in clinical practice comes from double-blind, placebo-controlled trials with adequate sample size, referred to in this chapter as Category A evidence. This le

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