Titlebook: Biophysics of Infection; Mark C. Leake Book 2016 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Natu

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Investigating the Swimming of Microbial Pathogens Using Digital Holography,out cells moving in three dimensions. We review the use of digital holographic microscopy for three-dimensional imaging at high speeds, and demonstrate its use for capturing the shape and swimming behaviour of three important model pathogens: ., . spp. and . spp.

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Evolution of Drug Resistance in Bacteria,mics of microbial populations affects the evolution of antibiotic resistance. We focus on the role of spatial and temporal drug gradients and show that in certain situations bacteria can evolve de novo resistance within hours. We identify factors that lead to such rapid onset of resistance and discuss their relevance for bacterial infections.

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How Biophysics May Help Us Understand the Flagellar Motor of Bacteria Which Cause Infections,comotive force for bacteria. This locomotion provides a key aspect of bacteria’s prevalence. Here, we outline the biophysics behind the assembly, the energetics, the switching and the rotation of this remarkable nanoscale electric motor that is Nature’s first wheel.

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Book 2016ing-edge research articles, laboratory protocols, case studies and up-to-date reviews cover topics such as single-molecule observation of DNA replication repair pathways in E. coli; evolution of drug resistance in bacteria; restriction enzymes as barriers to horizontal gene transfer in Staphylococcu

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Developmentalism and Social Change in Chiledoubt on the use of the MIC as ‘a measure of the concentration needed for peptide action’ and show how ‘coarse-grained’ studies at the population level give vital information for the correct planning and interpretation of MIC measurements.

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Sociology of Developing Societiesons for flows in a thin film with general slip boundary conditions, and establish connections between theoretical and experimental results. This article aims to highlight the importance of mathematics as a tool to unlock qualitative mechanisms associated with experimental observations in the medical and biological sciences.