Titlebook: Biophysical approaches to translational control of gene expression; Jonathan D. Dinman Book 2013 Springer Science+Business Media New York

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A Multidisciplinary Approach to RNA Localisation,f model developmental systems mRNA localisation has been shown to play a key role in setting up embryonic axes. Furthermore, in the nervous system RNA localisation is thought to play a central role in synaptic plasticity, memory and learning. Important advances in our understanding of the mechanism

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Virtual Screening for RNA-Interacting Small Molecules,discovery. The discovery of a broad range of important biological processes involved by RNA has increased the importance of RNA as a new drug target. To apply structure-based virtual screening methods to the discovery of RNA-binding ligands, many RNA 3D structure prediction programs and optimized do

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,The “Fifth” RNA Nucleotide: A Role for Ribosomal RNA Pseudouridylation in Control of Gene Expressio the majority of species. The isomerization of uridine to pseudouridine on rRNA has important implications not only for ribosome structure but also for ribosome function. Structural and functional studies of both prokaryotic and eukaryotic ribosomes have revealed that pseudouridylation may regulate

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Translational Control of Synaptic Plasticity and Memory, transmission in response to neuronal activity or different neuromodulators. Long-lasting activity-dependent synaptic plasticity requires new gene expression. While the role of transcription-mediated gene expression in synaptic plasticity and memory is well established, the mechanisms underlying tra

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Jonathan D. DinmanConsists of up-to-date and comprehensive reviews of research and relevant new imaging and structural approaches.Addresses major advances in researching cell’s molecular machinery through analytical, c

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Biophysics for the Life Scienceshttp://image.papertrans.cn/b/image/188350.jpg

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Late Cold War Literature and Culturechaea consist of a large (50S) and a small (30S) subunit, which together compose the 2.5 megadalton (MDa) 70S ribosome. Their eukaryotic counterparts are the 60S and 40S subunits and the 80S ribosome (from 3.5 MDa in lower eukaryotes to 4.5 MDa in higher). Many ribosomal key components are conserved

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https://doi.org/10.1057/978-1-137-51308-3s with several translation factors and undergoes extensive conformational changes which are integral part of the translation process. Cryo-Electron Microscopy with powerful image-processing software has contributed immensely for elucidating those dynamic structural events; thereby our understanding

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https://doi.org/10.1007/978-3-030-56454-4hesis. Single molecule studies yield time-resolved measurements with low spatial resolution. Currently, there is no experimental technique capable of producing time-resolved trajectories of the ribosome with atomistic resolution. Computer simulations are critical for furthering our understanding of

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