Titlebook: Biomolecular Interfaces; Interactions, Functi Ariel Fernández Stigliano Textbook 2015 Springer International Publishing Switzerland 2015 Bi

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The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology,gment of how exquisitely the structure of proteins and their aqueous environment are dynamically entangled attests to the overdue recognition that the biomolecular phenomena cannot be effectively understood without dealing with interfacial behavior. There is an urge to grasp how biological behavior

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sparse

Osteoporosis

Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface,family may be exploited to enhance drug specificity. This finding is noteworthy since homologous proteins are known to share a common structure topology and therefore, telling them apart through molecular recognition becomes a particularly arduous problem.

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Evolution of Protein Structure Degradation and Lessons for the Drug Designer,d malignancy. In assessing the evolutionary forces that promote differences in the dehydron patterns across orthologous proteins (homologs from different species), we came across the surprising finding that random genetic drift plays a central role in causing dehydron enrichment. This type of struct

ABYSS

Chemical Functionality of the Aqueous Interface in Soluble Proteins,splacement coordinate, we show that nucleophilic groups are functionally enabled by nearby dehydrons. The computations are validated against experimentally evidence on specific . decreases at functional sites and on degenerative deregulation of catalytic activity arising from dehydron-generating mut

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