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Titlebook: Biomolecular Interfaces; Interactions, Functi Ariel Fernández Stigliano Textbook 2015 Springer International Publishing Switzerland 2015 Bi

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发表于 2025-3-21 18:00:12 | 显示全部楼层 |阅读模式
期刊全称Biomolecular Interfaces
期刊简称Interactions, Functi
影响因子2023Ariel Fernández Stigliano
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发行地址Casts new light on bio molecular interactions.Will be of interest to researchers and graduate students in chemistry, biophysics and biomedical engineering.Problems and solutions in each frontier topic
图书封面Titlebook: Biomolecular Interfaces; Interactions, Functi Ariel Fernández Stigliano Textbook 2015 Springer International Publishing Switzerland 2015 Bi
影响因子.The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior..The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, .epistructural biology., centered on the interactions of water and bio molecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering..
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发表于 2025-3-21 21:06:21 | 显示全部楼层
Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water,alysis is the breakdown of the Debye . that postulates the alignment of water polarization with the protein electrostatic field. The complexities of biological interfaces are shown to be in good measure due to this departure from the standard dielectric picture that has been historically extrapolate
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Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistaches to the problem. The structural approach focuses on the molecular basis of cooperativity. We explore the concept of protein wrapping, its intimate relation to cooperativity, and its bearing on the expediency of the folding process for single-domain natural proteins. As previously described, wra
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Wrapping-Based Re-engineering of an Anticancer Drug to Make it Safer,ell fate or proliferation. These strategies target kinases, the signal transducers in the cell. This approach remains challenging because kinases are evolutionarily and therefore structurally related and thus kinase inhibitors (KIs) often lack the required specificity, which may lead to toxic side e
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Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine,ersal selectivity filter, applicable to the entire human kinome—even to kinases with unreported structure——and to idiosyncratic variations of the kinome would be truly useful for the drug designer. This chapter thematically belongs to the bioinformatics realm and addresses this issue at the broadest
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