Titlebook: Biomedical Engineering Technologies; Volume 2 Avraham Rasooly,Houston Baker,Miguel R. Ossandon Book 2022 The Editor(s) (if applicable) and

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978-1-0716-1813-4The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines

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Labor Markets in a Globalizing Worldind cancer cells that are clinically undetectable. Recent evidence has shown that subpopulations of these residual cancer cells enter into a prolonged dormant state, remaining quiescent for months to years, and eventually lead to metastases and relapse (Sosa et al. Nat Rev Cancer 14:611–622, 2014).

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Binh T. Nguyen,Loi Chi Cu,Chien Thang Nguyen microenvironment drives disease progression as well as therapeutic resistance. A number of challenges arise for researchers examining these cell-microenvironment interactions: (1) Tissue microenvironments are combinatorial and dynamic systems, and in pathological situations like cancer, microenviro