Titlebook: Biomedical Aspects of Drug Targeting; Vladimir Muzykantov,Vladimir Torchilin Book 2002 Springer Science+Business Media New York 2002 Epoxi

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Book 2002ncy and unwanted side effects. This concern is even more profound when using highly potent and cytotoxic anticancer drugs or specific agents, such as enzymes and genetic materials, since their effective and safe action requires precise cellular or even sub-cellular addressing in the target organ. To

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https://doi.org/10.1007/978-3-642-71455-9the heart. This chapter will focus primarily on targeting the oncotic myocardium. Targeting the apoptotic myocardium will not be considered in detail, but an introduction to the latest advances will be provided.

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https://doi.org/10.1007/978-3-322-81190-5unique EPR effect for tumor-targeted delivery of drugs. Thus, polymeric drugs and microparticles, including micellar compounds or liposomes, can be delivered with greater selectivity to tumors because of the EPR effect.

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Enhanced Permeability and Retention (EPR) Efect: Basis for Drug Targeting to Tumorunique EPR effect for tumor-targeted delivery of drugs. Thus, polymeric drugs and microparticles, including micellar compounds or liposomes, can be delivered with greater selectivity to tumors because of the EPR effect.

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Ligand-Directed Destruction of Tumor Vasculatureutant endothelial cells lacking the target antigen is unlikely because they comprise a normal, genetically stable cell population. Finally, since tumor vessels share common morphological and biochemical properties, this strategy should be applicable to different tumor types.

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