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Titlebook: Biomedical Aspects of Drug Targeting; Vladimir Muzykantov,Vladimir Torchilin Book 2002 Springer Science+Business Media New York 2002 Epoxi

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期刊全称Biomedical Aspects of Drug Targeting
影响因子2023Vladimir Muzykantov,Vladimir Torchilin
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图书封面Titlebook: Biomedical Aspects of Drug Targeting;  Vladimir Muzykantov,Vladimir Torchilin Book 2002 Springer Science+Business Media New York 2002 Epoxi
影响因子Drugs usually have no natural affinity for the cells, tissues and organs where therapeutic effects are needed, which frequently results in low efficiency and unwanted side effects. This concern is even more profound when using highly potent and cytotoxic anticancer drugs or specific agents, such as enzymes and genetic materials, since their effective and safe action requires precise cellular or even sub-cellular addressing in the target organ. To meet safety, efficiency and specificity requirements, drugs somehow must be targeted to the sites of their expected therapeutic action. The idea of the "magic bullet," or drug targeting, proposed by Erlich a century ago, generates great and continuously growing interest in biomedical, industrial and financial circles. This book is focused on the strategies designed to target therapeutic or diagnostic agents to the disease sites. In an attempt to include in this volume the set of chapters reflecting both traditional and emerging areas of drug targeting, we have contacted many leading scientists in the field asking for their contributions. Their responses were most favorable and encouraging. As a result, we have succeeded in assembling a ser
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attempt to include in this volume the set of chapters reflecting both traditional and emerging areas of drug targeting, we have contacted many leading scientists in the field asking for their contributions. Their responses were most favorable and encouraging. As a result, we have succeeded in assembling a ser978-1-4419-5312-4978-1-4757-4627-3
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Tissue-Specific Pharmacodelivery and Overcoming Key Cell Barriers in Vivo: Vascular Targeting of Cavthe ability of many monoclonal antibodies to reach their cell-specific antigens and thus to achieve effective tissue- or cell-directed pharmaco-delivery in vivo (1–3). Understanding general and selective transport across key cell barriers to pharmaco-delivery in vivo is fundamental to achieving effe
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Regel-orientierte Programmierungulation or hyperactivity intravascularly, neoexpression or hyperexpression of various vascular adhesion molecules, or the metabolites that may be incorporated into the cellular components of the atherosclerotic lesions may provide novel and specific diagnostic and therapeutic applications.
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Rüdiger Esser,Elisabeth Feldmarthe ability of many monoclonal antibodies to reach their cell-specific antigens and thus to achieve effective tissue- or cell-directed pharmaco-delivery in vivo (1–3). Understanding general and selective transport across key cell barriers to pharmaco-delivery in vivo is fundamental to achieving effe
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Sheng Qu,Xianliang Shi,Guowei Huaomponent has largely been ignored. Calculations of tumor cell loss have revealed that, in contrast to normal tissues, 30–80% of the progeny of tumor cell divisions shortly undergo degeneration. In tumors, the imperfect vasculature and impaired phagocytic response permit the accumulation of degenerat
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