Titlebook: Biomarkers of the Tumor Microenvironment; Lars A. Akslen,Randolph S. Watnick Textbook 2022Latest edition The Editor(s) (if applicable) and

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Molecular Phenotypes of Endothelial Cells in Malignant Tumors tumor blood vessels exhibit distinctly abnormal molecular phenotypes compared to their normal counterparts. As noticed by Aird: “The phenotypes of endothelial cells vary in structure and function, in space and time, and health and disease.” The palette of tumor endothelial phenotypes results from t

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KEGEL

Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support?as questioned the exclusive tumor-supportive function of the tumor stroma and suggested that the stroma might also act as a barrier to inhibit tumor metastasis. With consideration of this shift in dogma, we discuss the role of a specific part of the tumor stroma, the insoluble extracellular matrix (

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Tissue Architecture in Cancer Initiation and Progressionundant throughout the body, where it lines organs to serve as a protective barrier against biological, chemical, and physical insults. As such, the maintenance of epithelial tissue architecture is critical for tissue homeostasis and healthy tissue functioning. The structure and function of epithelia

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Tumor-Fibroblast Interactions in Carcinomase stroma is comparable to the activated stroma at the site of wound healing. The crosstalk between malignant cells and the surrounding stromal fibroblasts, an essential part of the reactive stroma, is a continuous, reciprocal force that modulates cancer progression. This communication unfolds at sev

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