Titlebook: Biomarkers for Preclinical Alzheimer’s Disease; Robert Perneczky Book 2018 Springer Science+Business Media, LLC 2018 Epidemiology.imaging.

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Soluble Amyloid Precursor Proteins in Blood: Methods and Challengesin cerebrospinal fluid do not seem to follow a consistent pattern, which limits their usefulness as diagnostic and prognostic tool. More recently, evidence has been presented for sAPP blood plasma concentration differences between patients with AD dementia and healthy control subjects. Blood can be

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Tau Imaging in Preclinical Alzheimer’s Diseasese (AD), Parkinson’s disease without (PD) and with later dementia (PDD), Lewy body dementia (LBD), frontotemporal dementia (FTD), and corticobasal degeneration (CBD). Aggregated tau tangles, the result of hyperphosphorylation, is a pathological characteristic of a group of neurodegenerative conditio

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Retinal Imaging in Early Alzheimer’s Diseaseges could be identified, it would contribute to a more accurate estimation of an individual’s risk of developing disease and enable the monitoring of high-risk (presymptomatic) persons as well as providing the means for assessing the efficacy of new interventions. The retina links to the visual proc

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In Vivo Volumetry of the Cholinergic Basal Forebrainpathogenetic aspect of Alzheimer’s disease (AD) and forms the rationale for the use of cholinomimetics as antidementive treatment. The role of the cholinergic deficit in AD pathophysiology has mainly been studied in experimental animal models and in neuropathologic examinations of human autopsy data

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Biomarkers for Preclinical Alzheimer’s Disease978-1-4939-7674-4Series ISSN 0893-2336 Series E-ISSN 1940-6045

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https://doi.org/10.1007/978-3-642-57462-7il threads consisting of hyperphosphorylated tau, extracellular parenchymal amyloid β plaques, and neuritic plaques. In this chapter, we describe the neuropathological criteria for the neuropathological diagnosis of Alzheimer’s disease, as well as the fixation, processing, and histology protocols required for the assessment of .-. human brains.

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Robert PerneczkyIncludes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts

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