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Titlebook: Biology of the Mammary Gland; Jan A. Mol,Roger A. Clegg Book 2002 The Editor(s) (if applicable) and The Author(s), under exclusive license

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Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) Potentially Regulates Programmed Cell Death important initiator of re-modelling of the extracellular matrix during mammary involution. A potential interaction between the cell death and extracellular matrix remodelling is evident from the observation that IGFBP-5 binds to plasminogen activator inhibitor-I (PAI- 1). We thus hypothesized that
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Somatostatin and Opioid Receptors in Mammary Tissue, (modulation ofsteroid receptors,proteases,secretion,interaction with cytoskeletalelements),will be discussed,takingintoconsiderationalso the possible local production of casomorphins (casein-derived opioids), which are very potent antiproliferative agents.
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Mammary Gland Development and the Prolactin Receptor,on. The recent availability of genetic mouse models provides new insights into mammary developmental biology and how the action of a hormone at specific stages of development can have effects later in life on processes such as mammary development and breast cancer initiation and progression.
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Targeting of PKA in Mammary Epithelial Cells,secretion to be localised to the early stages of the secretory pathway. Possible mechanisms are considered for the physical targeting of PKA to the membrane-enclosed components of the secretory pathway and evidence for their occurrence in mammary epithelial cells is presented.
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