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Titlebook: Biology of Vascular Smooth Muscle; Vasoconstriction and Yuansheng Gao Book 2022Latest edition The Editor(s) (if applicable) and The Author(

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NeurotransmittersP, neuropeptide Y, vasoactive intestinal peptide, nitric oxide, calcitonin gene-related peptide, substance P, and others. Some of them are vasoconstrictors and some are vasodilators. The balance of the activity of these neurotransmitters is critical for the integrity of vascular function.
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Shear Stress, Myogenic Response, and Blood Flow Autoregulationood pressure causes vasodilation, a phenomenon known as myogenic response. Vascular myogenic response is initiated by the opening of mechanosensitive ion channels such as TRPC6 channel, TRPM4 channel, epithelial sodium channel (ENaC) proteins and closely related acid-sensing ion channels, P2X7purine
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Intracellular Ca2+ Regulationgh store-operated calcium channels with STIM1 as Ca. sensor and Orai and TRPC1 proteins as channels for Ca. entry. In this chapter, the above mechanisms and their physiological relevance to vascular activities are discussed.
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