Titlebook: Biological Reactive Intermediates IV; Molecular and Cellul Charlotte M. Witmer,Robert R. Snyder,I. Glenn Sipe Book 1991 The Editor(s) (if a

extemporaneous

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Metabolism of Drugs by Activated Leukocytes: Implications for Drug-Induced Lupus and Other Drug Hype which makes them difficult to prevent, and because they are associated with a relatively high mortality rate. General agreement on the definition of an idiosyncratic reaction is lacking, but the term will be used to mean a reaction that does not occur in most patients given the drug even at a high

Heterodoxy

Formation of a Protein-Acetaldehyde Adduct in Liver during Chronic Alcohol Exposured by two alcohol metabolizing systems: alcohol dehydrogenase (ADH) (Li, 1977) and the microsomal ethanol oxidizing system (MEOS or cytP450IIE1) (Lieber et al., 1970). In individuals who do not abuse alcohol, ADH is the most important enzyme responsible for the conversion of ethanol to acetaldehyde.

LEVER

Dose-Response Relationships in Chemical Carcinogenesis: From DNA Adducts to Tumor Incidencend saturation of enzymatic activation and detoxification processes and of DNA repair affect the relationship between dose and steady-state DNA adduct level; (ii) The fixation of DNA adducts in the form of mutations is accelerated by stimulation of the cell division, for instance due to regenerative

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The Single Cell Gel (SCG) Assay: An Electrophoretic Technique for the Detection of DNA Damage in Indince the effects of many reactive intermediates are tissue and cell-type specific, it is important to utilize techniques which can directly detect DNA damage in individual cells. Cytogenetic techniques, while providing information at the level of the individual cell, are largely limited to prolifera

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