Titlebook: Biological Reactive Intermediates IV; Molecular and Cellul Charlotte M. Witmer,Robert R. Snyder,I. Glenn Sipe Book 1991 The Editor(s) (if a

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Biological Significance of Active Oxygen Species: In Vitro Studies on Singlet Oxygen-Induced DNA Damve Intermediates III (Wefers and Sies, 1986), work from our laboratory has been presented comprehensively (Sies, 1986, 1988; Ishikawa and Sies, 1989). Further, the biochemistry of oxygen toxicity has been presented (Cadenas, 1989).

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Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/b/image/187441.jpg

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978-1-4684-5879-4The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines

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Technische Hilfswissenschaften,e has been accrued over the years to support the view that the majority of chemical carcinogens require bioactivation in order to elicit tumor initiation, and many toxic chemicals other than carcinogens also require bioactivation. The P-450 enzymes are probably involved to a greater extent than any

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Klingelnberg Technisches Hilfsbuchechanism for the termination of drug action. Metabolism may quantitatively alter drug action and may also convert pharmacologically inactive prodrugs to their pharmacologically active metabolites. In addition, metabolism of xenobiotics to polar, readily excretable metabolites is a major detoxication

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