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Titlebook: Biological Methylation and Drug Design; Experimental and Cli Ronald T. Borchardt,Cyrus R. Creveling,Per Magne U Book 1986 The Humana Press

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,Interessen — Gemeinwohl — Gemeinsinn,cytosine in DNA led to the suggestion that this minor base derived from post-replication modification of DNA (Romberg .., 1959). Subsequent studies showed that DNA modification in prokaryotes is part of the host range restriction system (Arber, 1968) and is also involved in strand selection in misma
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,Interessen — Gemeinwohl — Gemeinsinn,c expression have been studied in the past 8 years with respect to their methylation pattern (for recent review, see Razin and Szyf, 1984). Investigators took advantage of the restriction enzymes HpaII (CCGG) and HhaI (GCGC) that are inactive when the internal cytosine residue in their recognition s
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,Brücke über die Simme in Garstatt, to show that tRNA modification serves as a mean to adapt cells to environmental changes, such as starvation or oxidation stress (Kersten, 1984; Buck & Ames, 1984). The metabolic control is triggered by specific alterations of tRNA modifications, caused by (i) changes in the levels or redox-state of
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Kleiner Ratgeber für den Apothekenkaufethylated cap structures in translation and mRNA stability has been demonstrated (Both et al., 1975), the function of internal methylation of specific adenine residues, to form N.-methyladenosine (m.A), is not clear. It has been suggested that m.A serves some nuclear role in precursor processing and
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