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Titlebook: Biological Methylation and Drug Design; Experimental and Cli Ronald T. Borchardt,Cyrus R. Creveling,Per Magne U Book 1986 The Humana Press

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期刊全称Biological Methylation and Drug Design
期刊简称Experimental and Cli
影响因子2023Ronald T. Borchardt,Cyrus R. Creveling,Per Magne U
视频videohttp://file.papertrans.cn/188/187405/187405.mp4
学科分类Experimental Biology and Medicine
图书封面Titlebook: Biological Methylation and Drug Design; Experimental and Cli Ronald T. Borchardt,Cyrus R. Creveling,Per Magne U Book 1986 The Humana Press
影响因子This book has been developed from its earlier and far less formal presentment as the proceedings of a symposium entitled The Biochemistry of S-Adenosylmethionine as a Basis for Drug Design that was held at the Solstrand Fjord Hotel in Bergen, Norway on June 30-July 4, 1985. The purpose of the symposium was to bring together scientists from various disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medicine, and so on) to discuss the recent advances that have been made in our understanding of the biological roles of S­ adenosylmethionine (AdoMet) and to discuss the feasibility of utilizing AdoMet-dependent enzymes as targets for drug design. Thus the information provided herein will be of value not only to basic scientists involved in elucidating the role of AdoMet in biology, but also to medicinal chemists who are using this basic knowledge in the process of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. Each plenary speaker at the symposium was requested to submit a chapter reviewing recen
Pindex Book 1986
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Is There a Function for Protein Carboxylmethylation in the Nervous System? role of this enzyme are 1) the nature and specificity of relevant . protein substrates; 2) the stoichiometry of protein carboxylmethylation and 3) the rapid hydrolysis of carboxylmethylesters under conditions of neutral and basic pH (Billingsley and Lovenberg, 1985). Thus, two major schools of thou
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Methylation of Phosphatidylethanolamine: Enzyme Characterization, Regulation and Physiological Functears. An introduction to the topic and its relationship to phospholipid metabolism has been published (Vance, 1985). A summary of the field until 1981 was published in the book originating from the 1981 Transmethylation Conference (Vance et al. 1982).
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Regulation of Phospholipid Methylation by Reversible Phosphorylationaño et al., 1980). Similarly, glucagon produces a transient accumulation of radioactivity into phospholipids in rat hepatocytes prelabeled with (methyl–3H)-methionine (Schuller et al., 1985). Exogenous cyclic AMP (Castaño et al., 1980) or chloropheny. thio-cyclic AMP (Pritchard et al., 1981), added
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