Titlebook: Biological Basis of Sex Differences in Psychopharmacology; Jo C. Neill,Jayashri Kulkarni Book 2011 The Editor(s) (if applicable) and The A

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Introduction to the Interaction Between Gonadal Steroids and the Central Nervous System,e testes in men and the functions of the reproductive tract. This chapter will provide an overview of some of the extragonadal effects of these hormones, focusing on the central nervous system, and the mechanisms of hormone action. Hormone synthesis and metabolism within the CNS will be discussed wi

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Differences in Sexual Behaviour in Male and Female Rodents: Role of Serotonin,hibits sexual behaviour. Most fundamental research on the involvement of 5-HT in sex has been performed in rats. Selective serotonin reuptake inhibitors (SSRIs) have comparable effects on male and female sexual behaviour in rats; they inhibit it but only after chronic administration. Activation of t

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Sex Differences in the Septo-Hippocampal Cholinergic System in Rats: Behavioral Consequences,r levels of acetylcholine (ACh), a critical neurotransmitter activating hippocampal circuits. We found that the ACh release in the dorsal hippocampus increases during the period of learning or exploration, exhibiting a sex-specific 24-h release profile. Moreover, neonatal increase in circulating and

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Importance of the COMT Gene for Sex Differences in Brain Function and Predisposition to Psychiatric factors contribute to these sex dimorphisms, but the individual genes have rarely been identified. The catechol-.-methyltransferase (COMT) gene, which encodes an enzyme that metabolises catechol compounds, including dopamine, is a leading candidate in this regard. COMT’s enzyme activity, and the ne

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Estrogens and Gonadal Function in Schizophrenia and Related Psychoses,ere is mounting evidence from clinical, epidemiological, and basic research that estradiol, the main component of estrogens, exerts protective effects in schizophrenia and related psychoses. Possible modes of action of this hormone in the brain have been suggested, and clinical intervention studies

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