Titlebook: Biological Basis of Alcohol-Induced Cancer; Vasilis Vasiliou,Samir Zakhari,Jan B. Hoek Conference proceedings 2015 Springer International

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Kasseler Edition Soziale Arbeitactivation via PtdIns 3 kinase. Changes in PTEN expression and/or activity have been identified in a variety of chronic hepatocellular disorders including obesity, NAFLD, NASH, and alcoholism. In cancer biology, PTEN is frequently mutated or deleted in a wide variety of tumors. Mutations, decreased

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Kasseler Edition Soziale Arbeitfully known. This study examines alcohol metabolism in . and its interaction with HPV-16 in the malignant transformation of oral keratinocytes. The acetaldehyde-producing strain . V2016 was analyzed for . genes and activities of alcohol and aldehyde dehydrogenases. . attachment to immortalized HPV-1

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Kinderschutzbezogene Zusammenarbeitcopic screening of 6,014 Japanese alcoholics yielded high detection rates of esophageal squamous cell carcinoma (SCC; 4.1 %) and head and neck SCC (1.0 %). The risks of upper aerodigestive tract SCC/dysplasia, especially of multiple SCC/dysplasia, were increased in a multiplicative fashion by the pr

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Sirikit Krone,Sybille Stöbe-Blosseyant risk factor for these cancers. Ethanol is oxidized primarily by alcohol dehydrogenases to acetaldehyde, an agent capable of initiating tumors by forming adducts with proteins and DNA. Acetaldehyde is metabolized by ALDH2, ALDH1B1, and ALDH1A1 to acetate. Retinoic acid (RA) is required for cellul

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Sirikit Krone,Sybille Stöbe-Blosseyajor health issues are associated with alcohol abuse, including colorectal cancer (CRC) and its metastatic growth to the liver. Although a correlation exists between alcohol use and the development of diseases, the search continues for a better understanding of specific mechanisms. Concerning the ro

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Ethnografie als Forschungsstrategie,ol consumption affects antitumor immunity and host survival have largely been unexplored. We studied the effects of chronic alcohol consumption on the immune system and antitumor immunity in mice inoculated with B16BL6 melanoma and found that alcohol consumption activates the immune system leading t

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https://doi.org/10.1007/978-3-319-09614-8acetaldehyde; cirrhosis; hepatocarcinogenesis; liver cancer