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Titlebook: Biological Basis of Alcohol-Induced Cancer; Vasilis Vasiliou,Samir Zakhari,Jan B. Hoek Conference proceedings 2015 Springer International

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期刊全称Biological Basis of Alcohol-Induced Cancer
影响因子2023Vasilis Vasiliou,Samir Zakhari,Jan B. Hoek
视频video
发行地址Explores effects of alcohol on cancer stem cells, metabolomics, biomarkers, and more.Challenges and updates the epidemiology of alcohol and cancer.Discusses how alcohol affects tissue-specific cancers
学科分类Advances in Experimental Medicine and Biology
图书封面Titlebook: Biological Basis of Alcohol-Induced Cancer;  Vasilis Vasiliou,Samir Zakhari,Jan B. Hoek Conference proceedings 2015 Springer International
影响因子In the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated. This proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013. The various topics explore the affects of alcohol on: liver and breast cancer; cell signaling and cancer; stem cells; biomarkers and metabolomics; aerodigestive cancers; cancer and the immune system and more.
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Alcohol and Cancer: An Overview with Special Emphasis on the Role of Acetaldehyde and Cytochrome P4g DNA repair and DNA methylation, ROS results in lipid peroxidation with the generation of lipid peroxidation products such as 4-hydoxynonenal which binds to DNA-forming highly carcinogenic exocyclic DNA adducts. ROS production correlates significantly with CYP2E1 in the liver but also in the esopha
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The Role of Iron in Alcohol-Mediated Hepatocarcinogenesis,lso strongly affected by alcohol. The few available studies suggest various molecular mechanisms that involve iron regulatory protein (IRP1), transferrin receptor 1 (TfR1), and the systemic iron master switch hepcidin, but not classical mutations of the HFE gene. Notably, reactive oxygen species (RO
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,Synergistic Toxic Interactions Between CYP2E1, LPS/TNFα, and JNK/p38 MAP Kinase and Their Implicatisms involved including activation of the mitogen-activated kinase kinase kinase ASK-1 as a result of CYP2E1-derived reactive oxygen intermediates promoting dissociation of the inhibitory thioredoxin from ASK-1. This activation of ASK-1 is followed by activation of the mitogen-activated kinase kinase
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,Alcohol Consumption, Wnt/β-Catenin Signaling, and Hepatocarcinogenesis,PF + DEN and chow + DEN groups, . < 0.05. Analysis of EtOH-treated livers from a previously published rat model of chronic liver disease revealed increases in hepatocyte proliferation accompanied by a hepatic depletion of retinol and retinoic acid stores (. < 0.05), nuclear accumulation of β-catenin
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Application of Mass Spectrometry-Based Metabolomics in Identification of Early Noninvasive Biomarkecould be distinguished from control animals. It also showed that a combined endogenous biomarker panel helps to identify subjects with ALD as well as those at risk of developing ALD even without any information on alcohol intake or genetics. Quantitative analysis showed that increased excretion of i
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Alcohol Metabolism by Oral Streptococci and Interaction with Human Papillomavirus Leads to Malignanspectively. . V2016 did not show a detectable aldehyde dehydrogenase. AdhE is the major alcohol dehydrogenase in .. Acetaldehyde and malondialdehyde production from permissible . species significantly increased the bacterial attachment to keratinocytes, which was associated with an enhanced expressi
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