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Titlebook: Bioinformatics; Volume II: Structure Jonathan M. Keith Book 2017Latest edition Springer Science+Business Media New York 2017 genotype.pheno

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https://doi.org/10.1007/978-3-642-94462-8ically improves reliability and accuracy of 3D models. This chapter discusses the use of structural information obtained from various paramagnetic NMR measurements and demonstrates computational algorithms implementing pseudocontact shifts as restraints to determine the structure of proteins at atomic resolution.
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Architektur u. Bauingenieurwesen,redicting function..This chapter proposes a pipeline of freely available Web-based tools to analyze protein-coding DNA and peptide sequences of unknown function. Accumulated information obtained during each step of the pipeline is used to build a testable hypothesis of function..The following methods are described in detail:
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https://doi.org/10.1007/978-1-4939-6613-4genotype; phenotype; systems of interacting elements; genome-wide association data; computational diagno
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https://doi.org/10.1007/978-3-642-94462-8ss rates in generating high quality models comparable to the accuracy of structures observed in X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy. A computational/experimental hybrid approach incorporating sparse experimental restraints in computational modeling algorithms drast
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