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Titlebook: Biochemistry of Signal Transduction in Myocardium; Jos M. J. Lamers,Pieter D. Verdouw Book 1996 Kluwer Academic Publishers 1996 Angiotensi

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Angiotensin II signalling pathways in cardiac fibroblasts: Conventional versus novel mechanisms in mnalling pathways in common with those of peptide growth factors. Below, we describe growth-related aspects of cardiac fibroblasts with respect to angiotensin II receptors, conventional and novel signal transduction systems, secretion of extracellular matrix proteins and growth factors, and localizat
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Regulation of G protein function: Implications for heart diseasemyopathies are associated with abnormal GPCR function, mutations are unlikely in these disorders. The last few years, other aspects of G protein function have moved into focus: e.g. posttranslational modifications; effector regulation by . subunits; GTPase activating protein (GAP) activity of effect
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Regulation and functional significance of phospholipase D in myocardium by agonists in myocardium is controversial. Agonists, such as endothelin-1, atrial natriuretic factor and angiotensin II that are shown to activate phospholipase D, also potently stimulate phospholipase C-β in myocardium. PMA stimulation of protein kinase C inactivates phospholipase C and strongly
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Phosphotransfer reactions as a means of G protein activationof G protein-coupled receptors for agonists and an increased response of G protein coupled effectors. In addition, a phosphorylation of G protein β subunits and consequent phosphate transfer reaction resulting in G protein activation has also been demonstrated. Finally, endogenously formed GTP was p
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