Titlebook: Biochemistry of Halogenated Organic Compounds; Kenneth L. Kirk Book 1991 Springer Science+Business Media New York 1991 Amino acid.Nucleoti

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Biochemistry of Halogenated Aldehydes and Ketones,yl group, making the carbonyl carbon more electrophilic, an effect especially pronounced with .-fluorine substitution. This has been used to advantage in the design of several transition state analogue enzyme inhibitors, based on the ready formation of tetrahedral intermediates from such halogen-substituted analogues.

PRISE

Biochemistry of Halogenated Analogues of Steroids, Isoprenyl Derivatives, and Other Terpenoids,d glucocorticoids will be given, followed by comments on other biomedical applications of halogenated steroids. The use of halogenated steroids as biological tracers and mechanistic probes will be discussed, with special attention given to recent research on the development of radiohalogenated steroids as steroid receptor-based imaging agents.

鲁莽

Biochemistry of Halogenated Neuroactive Amines,o the benefit or detriment of the subject. Accordingly, the role of halogenated analogues in the development of psychotherapeutic and psychotomimetic drugs will be discussed. Analogues that have peripheral cardiovascular action also will receive special attention.

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https://doi.org/10.1007/978-3-662-08196-9titution (leukotrienes). These compounds, collectively named eicosanoids, are derived enzymatically from C-20 acids, most notably arachidonic acid, as shown in Fig. 4-1 (the “arachidonic acid cascade”). A recent review of the biosynthesis, nomenclature, and physiological role of eicosanoids is provided by Moore (1985).

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Beeinflussung der Lebenslaufkosten,o-workers, based in part on the precedent provided by the altered biological activity of fluorocitrate, was a second development of historical proportions (Chapter 3). Of comparable scientific impact was the synthesis of 5-fluorouracil (fl.ura), 5-fluoroorotic acid (fl.oro), and 5-fluorocytosine (fl.cyt) (Fig. 5-1) by Heidelberger .. (1957).

藕床生厌倦

Biochemistry of Halogenated Nucleosides and Nucleotides,o-workers, based in part on the precedent provided by the altered biological activity of fluorocitrate, was a second development of historical proportions (Chapter 3). Of comparable scientific impact was the synthesis of 5-fluorouracil (fl.ura), 5-fluoroorotic acid (fl.oro), and 5-fluorocytosine (fl.cyt) (Fig. 5-1) by Heidelberger .. (1957).

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