Titlebook: Biochemistry of Diabetes and Atherosclerosis; James S. C. Gilchrist,Paramjit S. Tappia,Thomas Ne Book 2003 Springer Science+Business Media

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Chronic diabetes alters function and expression of ryanodine receptor calcium-release channels in rshed that the release of calcium ions from internal sarcoplasmic reticulum via type 2 ryanodine receptor calcium-release channels (RyR2) is vital for efficient contraction, the relationship between diabetes-induced decrease in cardiac performance and alterations in expression and/or function of RyR2

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The relationship between QTc interval and cardiac autonomic neuropathy in diabetes mellitus,ons in diabetic patients, which may also involve cardiovascular system. Autonomie system abnormality may increase QTc interval. On the other hand patients with prolonged QTc interval are prone to ventricular arrhythmias, especially unique torsade-de-point and also sudden cardiac death. This study in

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Antioxidants decreases the intensification of low density lipoprotein , peroxidation during therapy coenzyme A (HMG-CoA) reductase inhibitors (statins) family are usually used as a very effective lipid-lowering preparations but they simultaneously block biosynthesis of both cholesterol and ubiquinone Q. (coenzyme Q), which is an intermediate electron carrier in the mitochondrial respiratory chain

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Native and minimally oxidized low density lipoprotein depress smooth muscle matrix metalloproteinass) degrade these proteins. Conversely, oxidized low density lipoprotein (LDL) is implicated in atherogenesis through, amongst other cellular effects, a stimulation of the deposition of collagen within the vascular lesion. The present study investigated the potential for an interaction between oxidiz

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Inhibition of glycation reaction in tissue protein incubations by water soluble rutin derivative,dney proteins was also increased (p < 0.05) with the addition of glucose in the incubation mixture, but completely suppressed by the presence of G-rutin. On the contrary, inhibition of FL and AGE formation by G-rutin was found to be comparatively less effective in bovine serum albumin than both musc

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Comparative analysis of the phenolic content of selected Chilean, Canadian and American Merlot red ations in Merlots from the United States. The lowest levels of rutin were observed in Canadian Merlots. Quercetin occurred at significantly higher levels in Chilean Merlots. Wine prices were inversely correlated with catechin concentration. Merlot wine represents a source of antioxidants that may ha

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Protein kinase B in the diabetic heart,ponse. Concurrent glucose uptake however, was not additive. Wortmannin abolished both insulin and isoproterenol stimulation of glucose uptake as well as PKB phosphorylation. In contrast to the above-mentioned results, the protein tyrosine phosphatase inhibitor vanadate, alone or in combination with

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,Inhibition of interleukin-1β convertase is associated with decrease of neointimal hyperplasia after1) in group 1 vs. group 2. A smaller maximal neointimal thickness (0.63 ± 0.28 vs. 1.75 ± 0.94 mm, p < 0.005) and a decreased maximal neointimal area (2.14 ± 1.29 vs. 5.03 ± 1.92 mm2, p < 0.005), assessed by computerized planimetry, were found in group 1 vs. group 2. Lower apoptotic indices of the n