Titlebook: Biochemistry of Diabetes and Atherosclerosis; James S. C. Gilchrist,Paramjit S. Tappia,Thomas Ne Book 2003 Springer Science+Business Media

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Effect of sarpogrelate on altered STZ-diabetes induced cardiovascular responses to 5-hydroxytryptamresent investigation we have studied the effects of sarpogrelate on 5-HT receptors in heart and platelets in streptozotocin (STZ)-diabetic rats. Diabetes was induced by a single tail vein injection of STZ (45 mg/kg) and sarpogrelate (1 mg/kg, i.p.) was administered daily for 6 weeks. Injection of ST

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Mitogen-activated protein kinases in the acute diabetic myocardium,ms resulting in contractile dysfunction. The present study was aimed to investigate the expression and activation of mitogen-activated protein kinases (MAPKs) and their possible role in the acute diabetic rat hearts. Rats were injected with single dose of streptozotocin (45 mg/kg, i.v.), and after 1

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The relationship between human cytomegalovirus infection and atherosclerosis development,sible etiological factor of AS. In our study, artery vascular tissue specimens derived from 75 patients with AS were studied for detection of HCMV immediately early (IE) and later (L) gene fragments by polymerase chain reaction (PCR) and . hybridization; sera collected from the same patients were ex

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Changes in substrate metabolism in isolated mouse hearts following ischemia-reperfusion,nd in disease states. Little information has been provided, however, about myocardial energy metabolism in mouse hearts. We measured glycolysis, glucose oxidation and palmitate oxidation (using .H-glucose, .C-glucose and.H-palmitate) in isolated working mouse hearts during normoxic conditions (contr

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A comparison between NMR and GCMS 13C-isotopomer analysis in cardiac metabolism,ble isotope carbon-13. .C-NMR studies of substrate oxidation are based on the assumption that the .C-enrichment of glutamate reflects that of 2-ketoglutarate (2-KG). This assumption appears reasonable; however, it has not been thoroughly validated. The higher sensitivity of GCMS enables the direct d