| 期刊全称 | Biochemistry of Apoptosis and Autophagy | | 影响因子2023 | Lorrie A. Kirshenbaum | | 视频video | | | 发行地址 | Covers all aspects of apoptosis.Chapters submitted from world renowned researchers.Unique in defining the relationship between the regulatory mechanisms | | 学科分类 | Advances in Biochemistry in Health and Disease | | 图书封面 |  | | 影响因子 | One of the most intriguing and compelling issues to impact contemporary biology to date is the concept that cell death is genetically regulated. Observations by Kerr and Wyllie, made more than 30 years ago on the basis of distinct morphological criteria, markedly distinguished apoptosis from classical cell death by necrosis. Apoptosis is a highly regulated, evolutionary conserved, genetic program of cell death essential for normal development and tissue homeostasis. The discovery of apoptosis as a regulated event and potentially amenable to therapeutic interventions has generated considerable excitement because it meant that disease entities resulting from either too much, or too little, apoptosis could be potentially cured with new therapies that target apoptosis..While there is little doubt that necrosis induced by massive cellular trauma is likely an unregulated event, several lines of investigation have challenged the dogma that necrotic cell death ismerely unregulated. Emerging data has shifted the paradigm in our thinking about necrosis as a regulated event..Autophagy is another cellular process that has received considerable attention over the past two decades and its remark | | Pindex | Book 2022 |
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发表于 2025-3-21 17:15:38
