Titlebook: Biochemistry and Cell Biology of Ageing: Part III Biomedical Science; J. Robin Harris,Viktor I. Korolchuk Book 2023 The Editor(s) (if appl

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Governance and Limited Statehoodt evidence surrounding the role of mitochondrial DNA mutations in the ageing process. It then focusses on more recent discoveries regarding the role of mitochondrial dysfunction in stem cell ageing and age-related inflammation.

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Justice: A Philosophical Reviewf damaged or misfolded proteins causes further reduction of proteasome activity. Abnormal proteins also accumulate as a result of age-related neurodegenerative diseases. Deficits in proteasome activity might be responsible for accumulation of protein aggregates and thus contribute to the pathology.

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Justice and the Defective Newbornm alterations in gene expression, translation, intracellular trafficking, and posttranslational modification of connexins. Connexin proteins are now known to “moonlight” and perform a variety of non-junctional functions in the cell, independent of gap junctions. Furthermore, connexin “hemichannels”

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Justice and the Claims of Future Generationst mining have compiled co-mentions of cell senescence and age-related diseases allowing an impartial ranking of the impairments most closely associated with this process. Following this schema, the evidence for the involvement of senescence in several highly ranked pathologies is reviewed, alongside

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https://doi.org/10.1007/978-3-658-25196-3ogical functions highlight a potential capacity for use as novel biomarkers for diagnosis, prognosis, and treatment outcomes in a variety of conditions including pathological ageing. CircRNA may also have potential as target for interventions that manipulate ageing and longevity. In this chapter, we

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Marco Fey,Aviv Melamud,Harald Müllervironment. Recent research has highlighted the important role of some microenvironment components that modulate cell–cell communication, thus spreading signals from damaged ageing cells to neighbor healthy cells, thereby promoting systemic ageing. Extracellular vesicles (EVs) are small-rounded vesic