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Titlebook: Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide; Ben Avi Weissman,Nahum Allon,Shlomo Shapira Book 1995 Springer Science

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期刊全称Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide
影响因子2023Ben Avi Weissman,Nahum Allon,Shlomo Shapira
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图书封面Titlebook: Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide;  Ben Avi Weissman,Nahum Allon,Shlomo Shapira Book 1995 Springer Science
影响因子A decade ago, for most scientists investigating various issues in life sciences the word "NO" was used in a negative context. It is astounding to observe how recently researchers are addressing the issue of NO, namely, nitric oxide, in over fifty publications weekly. Science journal, while naming nitric oxide: "Molecule of the Year" (December 1992), said it all: "NO news is good news. " For a long period of time NO was considered as a pollutant and every ecology­ minded person tried to eliminate it. It was the discovery of NO involvement in the process of host killing by macrophages and several years later the finding that EDRF is none else but NO, that promoted this field. Nitric oxide‘s major role in the control of blood pressure is merely one factor of an extensive list of effects and functions attributed to it. NO is implicated in long-term potentiation (LPT), a principal process involved in memory consolidation and it is considered as the main biochemical substance responsible for penile erection. It should be noted that additional roles for NO are discovered continuously as many laboratories join the quest for the mystery of this small molecule. The observation that NO is inv
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Dietmar Sturzbecher,Detlef Landuammunication. This review is intended to describe and summarize some of our observations and those of other laboratories that have helped lead us and others to our present understanding of the nitric oxide-cyclic GMP signal transduction system. Readers are also referred to some of our earlier reviews
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https://doi.org/10.1007/978-3-663-06743-6tinct isoforms of NOS occur in mammals including a brain isoform (bNOS) that produces NO having a poorly defined role in neurotransmission (3,4), an isoform in vascular endothelial cells (eNOS) that produces NO having a vasodilatory role in normal blood pressure homeostasis (5,7), and an inducible i
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https://doi.org/10.1007/978-3-663-06743-6biological processes. NO is generated in a Ca.-dependent enzymatic reaction from the amino acid L-arginine. As a potent activator of soluble guanylyl cyclase (sGC), NO exerts many of its effects through intracellular accumulation of the nucleotide cycic GMP (cGMP), which acts on multiple intracellul
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Berufswahl und Berufsaussichten Jugendlichercompounds have more recently captured the attention of biologists in several different lines of research: the study of the antimicrobial effects of nitrites (2), the biotransformation of organic nitrates (3), and the identification of endothelium derived relaxing factor (EDRF)(4). In each of these a
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Jugend in der Gegenwartsgesellschaftnous outflow restriction. Recent work suggests that the initial step, cavernous and vascular smooth muscle relaxation, is mediated by the synthesis and release of nitric oxide from nerves innervating vascular and cavernous smooth muscles (Ignarro et al., 1990; Holmquist et al., 1991; Rajfer et al.,
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