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Titlebook: Biochemical Messengers; Hormones, neurotrans D. G. Hardie Book 1991 Springer Science+Business Media Dordrecht 1991

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期刊全称Biochemical Messengers
期刊简称Hormones, neurotrans
影响因子2023D. G. Hardie
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图书封面Titlebook: Biochemical Messengers; Hormones, neurotrans D. G. Hardie Book 1991 Springer Science+Business Media Dordrecht 1991
影响因子The central theme of this book is that systems of cell-cell signalling via nerves, hormones, local mediators and growth factors are not distinct phenomena, but branches of one general mechanism. These topics therefore can and should be discussed in an integrated manner, and the division of cell signalling studies into separate pigeonholes such as neuroscience, endocrinology or cancer biology is unnecessary, if not counterproductive. I also believe it to be unfortunate that there is not a collective term to describe neurotransmitters, hormones, local mediators and growth factors, other than clumsy phrases such as "extracellular signal molecule". The lack of a short and distinctive word for these entities genuinely hampers people from thinking about them in an integrated way. Having decided that it was presumptuous to invent a new term, I have chosen in this book the term first messenger to cover all types of extracellular signal molecule, because of the widespread acceptance of the term second messenger to represent the intracellular signal molecules that are produced in response to many of them. I have given the book the title "biochemical messengers", which is a global term to cov
Pindex Book 1991
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Book 1991mena, but branches of one general mechanism. These topics therefore can and should be discussed in an integrated manner, and the division of cell signalling studies into separate pigeonholes such as neuroscience, endocrinology or cancer biology is unnecessary, if not counterproductive. I also believ
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inct phenomena, but branches of one general mechanism. These topics therefore can and should be discussed in an integrated manner, and the division of cell signalling studies into separate pigeonholes such as neuroscience, endocrinology or cancer biology is unnecessary, if not counterproductive. I a
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Structure and Biosynthesis of First Messengers,the first messengers are related to those common metabolites, and the metabolic pathways which interconvert them. The structure and synthesis of peptide messengers exhibits several features which are rather unique and sets them apart from the synthesis of other proteins, and they will be discussed separately at the end of the chapter.
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Cell Biology of First Messenger Synthesis and Secretion,metabolite (glucose), some of these vesicles fuse with the plasma membrane (Figures 5.1) to release their contents into the extracellular fluid (Figure 5.2). Exocytosis can also be visualized dramatically by electron microscopy of mast cells, which secrete the mediator histamine (see Figure 6.1).
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