Titlebook: Bioactive Lipid Mediators; Current Reviews and Takehiko Yokomizo,Makoto Murakami Book 2015 The Editor(s) (if applicable) and The Author(s)

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Introduction: Gendering Gerson,ceptors (GPCRs). Notably, recent studies of lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles .. In addition, recent studies have identified several GPCRs for other lysophospholipids such as lysophosphatidylserine (LysoPS) and lysophosphatidylinositol

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Genders and Sexualities in Historyunctions are impaired, leading to various disorders. Complex sphingolipids are degraded to sphingosine by the actions of a series of lysosomal hydrolases, mutations in the genes of which are known to be responsible for approximately ten sphingolipid storage diseases to date. The resultant sphingosin

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D’Alembert’s Dynamic Conceptionsse translocates lipids from the exocytoplasmic to the cytoplasmic leaflet of cellular membranes, floppase mediates the translocation of lipids in the opposite direction, and scramblase facilitates bidirectional translocation of lipids. These specialized lipid transport machineries are now demonstrat

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Studies in History and Philosophy of Sciencers. LPA is produced by specific enzymatic reactions and activates receptors with similar structures (Edg receptors and P2Y receptors), which results in a variety of actions from embryonic blood vessel formation to development of cancer. LPA-related genes are highly conserved in vertebrates. In the z

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