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Titlebook: Bioactive Lipid Mediators; Current Reviews and Takehiko Yokomizo,Makoto Murakami Book 2015 The Editor(s) (if applicable) and The Author(s)

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发表于 2025-3-21 16:29:24 | 显示全部楼层 |阅读模式
期刊全称Bioactive Lipid Mediators
期刊简称Current Reviews and
影响因子2023Takehiko Yokomizo,Makoto Murakami
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发行地址Provides a comprehensive summary of recent studies on lipid mediators and related molecules.Offers step-by-step procedures for analysis of lipid mediators and their receptors.Suggests new drug targets
图书封面Titlebook: Bioactive Lipid Mediators; Current Reviews and  Takehiko Yokomizo,Makoto Murakami Book 2015 The Editor(s) (if applicable) and The Author(s)
影响因子.This book summarizes the most recent progress in the studies of lipid mediators from the molecular to clinical level and introduces newly created tools for analysis including imaging mass spectrometry. Comprising 29 chapters divided into four major parts, the book describes the molecular natures of enzymes, transporters, and receptors for lipid mediators (Part I), the function of lipid mediators in Drosophila and Zebrafish (Part II), the relationships between lipid mediators and various diseases (Part III), and detailed procedures of extraction, preparation, and quantification of lipid mediators (Part IV). Research on lipid mediators initially started with analysis of the action of aspirin, and subsequent biochemical experiments identified many enzymes and receptors responsible for the biosynthesis and signal transduction of individual lipid mediators. Through the phenotypic analyses of transgenic and knockout mice, it has been shown that the dysregulation of some lipid mediators causes inflammatory, immune, or oncogenic disorders. Lipid mediators have attracted increased attention because their structures are conserved among different species, and their biosynthetic and signaling
Pindex Book 2015
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发表于 2025-3-21 21:27:49 | 显示全部楼层
Phospholipase A2 serve as lipid mediators or their precursors. Mammalian genomes encode genes for more than 30 PLA.s or related enzymes, which are subdivided into several groups on the basis of their structures, enzymatic properties, and evolutional relationships. Among them, the Ca.-dependent cytosolic PLA. (cPLA.
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Pathophysiological Roles of Prostanoid Receptors in the Central Nervous Systems of these receptors have been clarified using knockout mice for each receptor as well as receptor-selective agonists and antagonists. In the central nervous system (CNS), prostanoids have been shown to regulate not only fever, but also neuroinflammation, and to play a role in the pathogenesis of ma
发表于 2025-3-22 10:43:47 | 显示全部楼层
Lipoxygenases: A Chronological Perspective on the Synthesis of , and , Fatty Acid Hydroperoxidesically forming a single chiral fatty acid hydroperoxide as product. The enzymes are best known for the synthesis of lipid mediators: for example, leukotrienes and resolvins in animals, jasmonates and short-chain aldehydes in plants. The first part of this review focuses on how and when the distingui
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Leukotriene B4 Receptorsidonic acid-derived metabolite produced by 5-lipoxygenase and LTA. hydrolase. To date, two leukotriene B. receptors, the high-affinity receptor BLT1 and the low-affinity receptor BLT2, have been cloned, and a systemic knockout mouse for each receptor has been generated. BLT1 is mainly expressed in l
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Fatty Acids Receptorst play significant roles in nutrition regulation. In this free fatty acid receptor family, FFAR1 (GPR40) and FFAR4 (GPR120) are activated by medium- and long-chain FFAs. FFAR1 regulates insulin secretion in pancreatic β-cells, whereas FFAR4 promotes the secretion of glucagon-like peptide-1 (GLP-1) i
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