Titlebook: Bile Acids and Their Receptors; Stefano Fiorucci,Eleonora Distrutti Book 2019 Springer Nature Switzerland AG 2019 Bile acids.Nuclear recep

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,Der elektrische Durchschlag in Isolierölen,n, and development. Upon activation by their ligands, NRs bind to their specific DNA elements, exerting their biological functions by regulating their target gene expression. Bile acids are detergent-like molecules that are synthesized in the liver. They not only function as a facilitator for the di

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,Der elektrische Durchschlag in Isolierölen,dial hormone regulating glucose homeostasis, glycogen and protein synthesis, and primary bile acid (BA) metabolism. In the ileum, BA-dependent farnesoid X receptor (FXR) activation induces the production of FGF19, which reaches the liver through the portal system where it represses the expression of

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,Über Elektrizitätsleitung in Isolierölen,lbladder. After a meal ingestion, BAs are reversed into the duodenum to facilitate the lipid absorption. At the intestinal level, the 95% of BAs are reabsorbed and redirected into enterohepatic circulation; indeed only a small amount of them are then subjected to chemical modifications by the intest

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https://doi.org/10.1007/978-3-642-50705-2lerosing cholangitis (PSC), and nonalcoholic steatohepatitis (NASH). NASH, in particular, is one of the last uncharted white territories in the pharma landscape, and there is a huge medical need and a large potential pharmaceutical market for a NASH pharmacotherapy. Clinical efficacy superior to mos

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Niels Lange,Thomas O. Hüglin,Thomas Jägervances in the understanding of BA physiology, and new insights have emerged regarding the role of BAs in determining cell damage and death in several liver diseases. This new knowledge has helped to better delineate the pathophysiology of cholestasis and the adaptive responses of hepatocytes to chol

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