Titlebook: Bayesian Adaptive Design for Immunotherapy and Targeted Therapy; Haitao Pan,Ying Yuan Book 2023 Springer Nature Singapore Pte Ltd. 2023 Ad

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Randomized Phase II Designs efficiency to handle the complexity of immunotherapies and targeted therapies that may involve binary, survival, ordinal, co-primary and multiple endpoints. A two-stage screened selection design (SSD) for randomized trials but without the control treatment is also introduced. Software to implement these designs are described.

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Introduction to Basket Trialscorporation of precision medicine into clinical trials. This chapter introduces several frequentist and Bayesian designs for basket trials, with a special focus on borrowing information across cancer types using Bayesian hierarchical model approaches. Software for some designs are described.

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lation study, proof-of-concept trials, and confirmatory studies with registrational. The book includes real-life examples and software to facilitate practitioners to learn and use the designs in practice..978-981-19-8467-9978-981-19-8176-0

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ive designs, such as model-assisted designs.Including many r.This book provides a comprehensive review of novel adaptive trial designs for targeted therapies and immunotherapies. This book covers a wide range of novel statistical designs for various clinical settings, including early phase dose-esca