Titlebook: BCL‑2 Protein Family; Essential Regulators Claudio Hetz Book 2010 The Editor(s) (if applicable) and The Author(s), under exclusive license

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Grace A. Mucci,Lilibeth R. Tornoastructure of the organelle, controlled by the balance between fusion and fission processes. Here we discuss recent findings pointing to a role for changes in mitochondrial morphology during apoptosis and how these might be regulated by members of the BCL-2 family.

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https://doi.org/10.1007/978-1-4899-7584-3 which precedes caspase activation, whereas inhibition of the mitochondrial fission machinery blocks or delays cell death. Aberrant mitochondrial fusion and fission have also emerged as important mechanisms in the development of disease.

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Alternative Functions of the BCL-2 Protein Family at the Endoplasmic Reticulum,in the control of diverse cellular processes including calcium homeostasis, autophagy and ER morphogenesis. Here we describe the emerging concept that BCL-2 family members are important regulators of essential cellular processes beyond apoptosis.

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Noncanonical Functions of BCL-2 Proteins in the Nervous System,l of antagonism between BCL-2 family proteins. Emphasis is logically placed on those phenotypes that support the model. However, this working model of BCL-2 family interactions has become so engrained that alternative, potentially valid interpretations are sometimes dismissed. Therefore, it is usefu

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,Later Nyāya Logic: Computational Aspects,ghly selective network of functional interactions that ultimately governs the permeabilization of the mitochondrial outer membrane and subsequent release of apoptogenic factors such as cytochrome ... The advent of loss- and gain-of-function genetic models for the various BCL-2 family proteins has no

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