Titlebook: Aging; How Science Works Carsten Carlberg,Stine M. Ulven,Eunike Velleuer Textbook 2024 The Editor(s) (if applicable) and The Author(s), und

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ic biology with clinical examples and hands-on care.Aging is a topic that concerns all of us, since none of us can escape it. The molecular and cellular process is built in every of the billions of cells forming our body. Some of these cells, such as immune cells and red blood cells, live only for a

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Molecular and Cellular Basis of Aging,e of apoptosis, autophagy and proteostasis are explained. In addition, stem cell exhaustion is described in the context of hematopoiesis and senescence together with tumor suppressor proteins like p53, RB1 (retinoblastoma 1) and p16. Finally, live expectance of cells is reviewed along telomere shortening and replicative immortality.

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Epigenetics, Memory and Aging,n clocks in the brain as well as in peripheral tissues support homeostasis of the body by coordinating a large set of physiological functions. Disturbing the day/night and feeding/fasting cycles can lead to numerous diseases and accelerated aging.

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Principles of Gene Expression and Epigenetics, and epigenetics, both of which are closely linked. In order to express a gene, ., to transcribe it into RNA, its regulatory regions need to be located within accessible chromatin. Chromatin is the physical representation of epigenetics. In a tissue- and cell type-specific fashion the majority of th

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Biochemistry of Aging,rogression of many chronic non-communicable diseases (Chap. .). The latter principles apply also to the process of aging. In this context, we provide an overview on nutrition-sensing pathways and their relation to aging and longevity. The molecular basis of this is the sensing of glucose and amino a

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Molecular and Cellular Basis of Aging,hagy, loss of proteostasis, stem cell exhaustion, cellular senescence and telomer attrition. Firstly, the handling of oxidative and metabolic stress in mitochondria and the endoplasmatic reticulum via SIRTs, AMPK and the unfolded protein response are discussed. Furthermore, the mechanisms and purpos