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Titlebook: Adrenoceptors; Jillian G. Baker,Martin C. Michel,Roger J. Summers Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusi

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发表于 2025-3-21 17:10:12 | 显示全部楼层 |阅读模式
期刊全称Adrenoceptors
影响因子2023Jillian G. Baker,Martin C. Michel,Roger J. Summers
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发行地址Adrenoceptors have been prototypes for rationale drug design and receptor structure and function.Adrenoceptors are target of guideline-recommended drugs for >30 diseases from heart to prostate.Most re
学科分类Handbook of Experimental Pharmacology
图书封面Titlebook: Adrenoceptors;  Jillian G. Baker,Martin C. Michel,Roger J. Summers Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusi
影响因子Adrenoceptors have been at the forefront of physiological and pharmacological research for a century. They served as prototypes for rationale drug design as recognized by a Nobel Prize to Sir James Black and for the molecular understanding and structure of G protein-coupled receptors as recognized by a Nobel Prize to Brian Kobilka and Robert J. Lefkowitz. Drugs directly or indirectly targeting adrenoceptors have become guideline-recommended treatments for more than 30 human and various animal diseases. This volume assembles leading experts on various types of adrenoceptor research to provide concise insight into the current standing and future direction of uses of adrenoceptor-targeted drugs and research in this field.
Pindex Book 2024
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Structures of Adrenoceptors,ne 2022) have been determined by X-ray crystallography and electron cryo-microscopy (cryo-EM) of all three βARs (β., β. and β.) and four out of six αARs (α., α., α., α.). The structures are in a number of different conformational states, including the inactive state bound to an antagonist, an interm
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Genetic Variants of Adrenoceptors,ll nine corresponding adrenoceptor genes display genetic variation in their coding and adjacent non-coding genomic region. Coding variants, i.e., nucleotide exchanges within the transcribed and translated receptor sequence, may result in a difference in amino acid sequence thus altering receptor fun
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Presynaptic Adrenoceptors, systems. Their activation by exogenous agonists leads to inhibition of the exocytotic release of noradrenaline and other transmitters from the neurons. Most often, the α.-receptor subtype is involved in this inhibition. The chain of molecular events between receptor occupation and inhibition of the
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,Asthma and COPD: A Focus on β-Agonists – Past, Present and Future, the most common chronic non-communicable diseases worldwide. Chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality worldwide, is caused by exposure to tobacco smoke and other noxious particles and exerts a substantial economic and social burden. This chapter revie
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