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Titlebook: Acute Myeloid Leukemia in Children; Standard of Care and Daisuke Tomizawa,Edward Anders Kolb,Dirk Reinhardt Book 2024 The Editor(s) (if app

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Germline Predisposition to MDS and AMLhe diagnosis of such syndromes, which involve genes such as ., ., ., ., .. This chapter describes these newly characterized leukemia predisposition syndromes’ genetic, biological, and clinical features.
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Chromosomal and Genomic Alterations in Pediatric AMLis and prognostication. Clinically significant alterations most often come in the form of fusion oncogenes, chromosome losses, and cancer gene mutations (e.g., single nucleotide variants, insertions/deletions, and internal tandem duplications). Genes that encode transcription factors and signal tran
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Diagnosis and Classifications of Pediatric AMLc AML, the most recent classification according to the World Health Organization, and how to diagnose AML. The basis for the initial bone marrow examination is morphological evaluation of bone marrow smear with or without trephine biopsy. Flow cytometry immunophenotyping is used to confirm AML and a
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Measurable Residual Disease Assessment in Pediatric AMLical decision making for patients with acute myeloid leukemia (AML). An appropriate MRD assay should include specificity and stability of the MRD biomarker(s) as well as high sensitivity. Given the heterogeneity of AML, the most appropriate MRD testing approach will be dependent on the biology of th
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