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Titlebook: Autoimmunity; Methods and Protocol Andras Perl Book 20041st edition Humana Press 2004

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Experimental Use of Murine Lupus Modelsphenotypes span the broad range of clinical manifestations of human lupus and consist of both spontaneous and experimentally induced disease in both inbred and targeted mutant animals. This chapter contrasts the clinical characteristics of these various models, providing an outline for the use and a
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1543-1894 evance of the model for a particular disease and for autoimmunity in general. Part I contains methods and protocols to assess immunological and biochemical pathways relevant for disease pathoge978-1-59259-805-2Series ISSN 1543-1894 Series E-ISSN 1940-6037
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,MoviA – Mobile virtuelle Absicherung,odulation of membrane clustering, aberrant cellular distribution, and precompartmentalization with lipid rafts invariably contributing to abnormal T-cell signaling in SLE T cells. The methods and protocols described here pertaining to T-cell signaling abnormalities in SLE T cells are very much optim
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,MoviA – Mobile virtuelle Absicherung,ression of numerous signaling molecules in SLE T cells. The contribution of each of these mechanisms in the abnormal expression of signaling molecules in SLE T cells is not known. In addition to abnormalities in gene expression, multiple factors, including altered cellular distribution of the protei
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Erfahrungen beim Ersten Aufstau,s of intracellular glutathione and ATP. Oxidative stress affects signaling through the T-cell receptor as well as the activity of redox-sensitive caspases. ATP depletion may be responsible for diminished activation-induced apoptosis and sensitize lupus T cells to necrosis. Mitochondrial dysfunction
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https://doi.org/10.1007/978-88-470-2799-2t (FCA)is injected subcutaneously into mice. The immune response, the histological changes, and the genetic susceptibility seen in EAM are similar to those of CB3-induced myocarditis. The third model is experimental autoimmune thyroiditis (EAT). EAT can be induced in genetically susceptible strains
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