Titlebook: Autoimmune Reactions; Sudhir Paul Book 1999 Springer Science+Business Media New York 1999 Antigen.antigen presentation.autoimmune disease.

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T-Cell Antigen Receptor Repertoire in Rheumatoid Arthritis,oral inflammatory response. T-cell response(s) to unknown antigen(s) are thought to be at the origin of RA, because early synovial histopathology resembles classic delayed type hypersensitivity and includes prominent infiltration consisting of antigen presenting dendritic cells clustered with CD4. T

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The Role of Exogenous Stimulation in Pathogenesis of Autoimmune Diseases,sm itself, which are allowed to persist, and the antigens borne by foreign molecules, which are disposed. Burnet .. proposed that the ability of immune system to distinguish “self and nonself ‘antigens results from the elimination of self-reactive lymphocytes during ontogenic development. This conce

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Dysregulation of the Idiotype Network in Autoimmune Diseases,ly assumed to reflect the acquisition of new antibody activities. However, it is now well recognized that some autoantibodies are also present in healthy individuals .. Recent evidence suggests that their expression may be regulated by an idiotype network ..

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The Role of Variable Region Gene Rearrangements in the Generation of Autoantibodies,mmunoglobulin coding sequences from multiple gene segments (VDJC and VJC for the heavy and light chains respectively). Combinatorial diversity—the random joining of different V, D, and J heavy chain segments or V and J light chain segments—leads to the production of a large number of immunoglobulin