Titlebook: Autoimmune Liver Diseases; Perspectives from Ja Hiromasa Ohira Book 2014 Springer Japan 2014 AIH.PBC.autoimmune hepatitis.primary biliary c

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Arthritis

https://doi.org/10.1007/978-3-662-11868-9hondrial inner membrane..The involvement of autoimmunity is considered due to the presence of both autoreactive CD4-positive T cells and CD8-positive T cells recognizing PDC-E2. Autoreactive NK cells are also involved in bile duct damage and in addition to acquired immunity, abnormalities in innate

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,Typische Größe von Konzernzentralen,Group in Japan supported by the Health Labour Sciences Research Grant. The subjects were 8,509 patients with PBC diagnosed and followed up between January 1, 1968 and December 31, 2011 at 520 hospitals and institutions throughout the country. We investigated the epidemiological trends and long-term

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Notwendigkeit und Aussagegehalt der Studie,these classical staging systems, PBC livers were classified into four stages on the basis of a single characteristic histological feature of PBC such as chronic nonsuppurative destructive cholangitis and bile ductular proliferation. It is well known that these histological features are heterogeneous

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https://doi.org/10.1007/978-3-322-99713-5in the development of accurate and sensitive solid-phase assays for the detection of antimitochondrial antibody (AMA), a small but substantial number of patients are still regarded as having AMA-negative PBC. PBC-specific antinuclear antibodies (ANAs) are thus valuable as complementary serological m

cardiovascular

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Models of Autoimmune Hepatitisnt of AIH. However, those models have lacked the characteristics of human AIH, such as hypergammaglobulinemia and production of circulating autoantibodies. In contrast, we have developed mouse models of spontaneous AIH with hypergammaglobulinemia and ANA production. Immune dysregulation by a concurr