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Titlebook: Autoimmune Diseases in Endocrinology; Anthony P. Weetman Book 2008 Humana Press 2008 Diabetes.Diabetes mellitus.Endocrinology.Internal med

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Type 1 Diabetes Mellitusan aggressive immune response, which can damage and even destroy it. Type 1 diabetes mellitus (T1DM), one such organ-specific autoimmune disease, is because of the destruction of the insulin-secreting beta cells in the islets of Langerhans of the pancreas. T1DM is because of the interaction of genet
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Animal Models of Autoimmune Thyroid Disease antigen that, based on current knowledge, seems to be of lesser importance in human AITD. Nevertheless, many of the basic precepts underlying autoimmunity, for example the importance of the major histocompatability complex (MHC) II and the existence of immunoregulatory T cells, have been identified
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Autoimmune Hypothyroidismnkly elevated TSH levels). Etiology and pathogenesis of chronic autoimmune thyroiditis and mechanisms leading to the hypothyroid phase remain elusive. However, some predisposing genetic factors and some triggering environmental factors have been identified. The role of antigen-presenting cells, of T
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Animal Models of Type 1 Diabetes Mellitusted to proinsulin/insulin as the primary autoantigen. Last but not least, when used adequately, animal models of T1D have also been helpful in preclinical studies to search for new immunointervention strategies applicable to the clinic. The overall conclusion of >30 years of studies conducted using
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