Titlebook: Attempts to Understand Metastasis Formation II; Regulatory Factors Ursula Günthert,Walter Birchmeier Book 1996 The Editor(s) (if applicable

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JAMB

Cerebrovascular

NM23/Nucleoside Diphosphate Kinase as a Transcriptional Activator of c-,,neoplastic development (Z. et al. 1993), normal development and differentiation (D. et al. 1988; B. et al. 1988, W. et al. 1990; Y. et al. 1994), proliferation (K. et al. 1992; O. et al. 1994), and cell motility (K. et al. 1993). All . genes encode the metabolic enzyme nucleoside diphosphate kinase

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Role of Tiam 1 in Rac-Mediated Signal Transduction Pathways,ith metastatic capacity, but direct evidence for a role of specific genes in metastasis is scarce. Products of oncogenes, such as Ras, can confer metastatic capacity (see C. et al. 1988), as can specific splice variants of CD44, of which the expression correlates with metastasis in model systems and

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Influence of c-, on the Progression of Human Breast Cancer,cal measures involve a number of parameters including the tumor size, histological type and grade, the presence of steroid receptors, and perhaps most importantly the status of the axillary lymph nodes (S. and P. 1992; F. 1992). The scope of this assessment is, however, significantly limited in pati

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Barriers to Participation in AET the microvascular endothelium and extracellular matrix of different areas contributes to the homing of metastases in specific organs (P. et al. 1990; A. et al. 1987; P. and L. 1988; R. et al. 1984; N. 1988). Attempts to identify endothelial cell surface components responsible for endothelial cell o

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Arrhythmia

Vertical Axis: Volume of Participationa model (B.-J. and R. 1984), while more recent work in the Dunning R-3327 rat prostatic adenocarcinoma model has further corroborated the relationship between motility and metastatic potential (M. et al. 1987, 1988; P. et al. 1989).

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,Formations of Style and Affiliation, cell that affect cell cycle progression also have a bearing on the therapeutic outcome. While the description of the changes affecting the G. to G. to S phase transition is currently better understand as regards malignancy, the G./M to phase transition also has important implications for therapy.