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Titlebook: Atlas Effectors of Anti-Tumor Immunity; Mikhail V. Kiselevsky Book 2008 Springer Science+Business Media B.V. 2008 Antigen.carcinoma.cell.i

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CD4+/CD25+ T-regulatory cells,ncreases with the long-term cultivation of lymphocytes in the presence of interleukine-2 and leads to down-regulation of the anti-tumor activity of lymphokine-activated killers. Therefore, activated lymphocytes obtained from an early period culture with IL-2 are preferable to include in adoptive immunotherapy.
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Natural killer T (NKT) cells: Immunophenotype, functional characteristics and significance in clininfiltrates that occur in liver and other organs of patients with cancer or infectious diseases. These cells have a large impact on the functional activity of effectors of anti-tumor and anti-infectious immunity.
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Formative Assessment and Feedback Toollecules. Interleukin-2 induces proliferation and activation of natural killer cells. Lymphocytes incubated in the presence of interleukin-2 are termed as lymphokine-activated killer cells. Lymphokine-activated killer cells have high proliferative activity and effectively lyse different types of tumor cells.
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