期刊全称 | Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis o | 影响因子2023 | Robert Doran | 视频video | | 发行地址 | Nominated as an outstanding Ph.D. thesis by University College Dublin, Ireland.Outlines the synthesis of a new bioactive lactone-containing natural product analog.Describes the development of a cataly | 学科分类 | Springer Theses | 图书封面 |  | 影响因子 | This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source. | Pindex | Book 2015 |
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