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Titlebook: Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis o; Robert Doran Book 2015 The Editor(s)

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发表于 2025-3-21 19:05:22 | 显示全部楼层 |阅读模式
期刊全称Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis o
影响因子2023Robert Doran
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发行地址Nominated as an outstanding Ph.D. thesis by University College Dublin, Ireland.Outlines the synthesis of a new bioactive lactone-containing natural product analog.Describes the development of a cataly
学科分类Springer Theses
图书封面Titlebook: Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis o;  Robert Doran Book 2015 The Editor(s)
影响因子This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.
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M. Ataharul Islam,Abdullah Al-Shihaylative protonation of the corresponding α-aryl-β-keto allyl esters. Enantioselectivities of up to 92 % . and 74 % . were achieved for cyclopentanone and cyclohexanone substrates, respectively. The route described gives access to these important structural motifs in moderate to high levels of enanti
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,Introduction to the Development of a Catalytic Asymmetric Synthesis of Tertiary α-Aryl Ketones,Biological systems recognise a pair of enantiomers as different substances and thus each enantiomer will trigger a different response. It is possible that one enantiomer could act positively as a therapeutic agent and the other enantiomer might be very harmful or toxic.
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Robert DoranNominated as an outstanding Ph.D. thesis by University College Dublin, Ireland.Outlines the synthesis of a new bioactive lactone-containing natural product analog.Describes the development of a cataly
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